Protein biomarkers for motor neuron disease

Motor Neuron Disease

Neurologists in the 19th century recognized that muscle weakness could be due to primary disorders of muscle or secondary to loss of neuromuscular integrity, as happens when peripheral nerves are cut or when motor neurons degenerate. Furthermore, it was observed that there are forms of motor neuron degeneration which selectively affect upper motor neurons or lower motor neurons. A combination o...

Assessing motor neuron disease.

Hadjikoutis and Wiles draw attention to a number of circumstances in which the serum chloride and bicarbonate can be misleading. They do not mention that they will also be misleading if they are measured when hypercapnia is increasing or decreasing. An exacerbation of hypercapnia will take 4 – 6 days to raise the serum bicarbonate and lower the serum chloride to new steady levels. 1 How long it...

Motor neuron disease

Motor neuron disease (MND) represents one ofthe major unsolved problems in neurology. The literature is characterized by numerous speculative theories, mostly derived by analogy with other recognized causes of motor neuron death such as poliomyelitis, or from toxic exposures such as lead poisoning. However, analogous reasoning of this type has not, so far, given insights into MND itself, or res...

Gene Therapy for Motor Neuron Disease

Environmental Health Factors for Motor Neuron Disease

Motor Neurone Disease (MND) is a progressive disease and once the symptoms are jointly evident enough to allow diagnosis, MND is a rapidly terminal disease. A plausible mechanism is the enhanced Apoptosis of the Motor Neurones leading to the loss of skeletal muscular control and strength. This has led to the development of a hypothesis that attempts to explain the overall evidence pattern, incl...